cruce Phar 7633 chapter 11 physiological factors affecting oral absorption return to the course index previous | next gastrointestinal (gi) physiology characteristics of gi physiology table 11. cheap generic viagra 3. 1 gi physiology and drug absorption washington et al. pills just like viagra , 2001 ph membrane blood supply surface area transit time by-pass liver buccal approx 6 thin good, fast absorption with low dose small short unless controlled yes esophagus 6-7 very thick, no absorption - small short, typically a few seconds, except for some coated tablets - stomach 1. 7-4. 5decomposition, weak acid unionized normal good small 30 min (liquid) - large integer min (solid food), delayed stomach emptying can reduce intestinal absorption no duodenum 5 - 7bile duct, surfactant properties normal good very large very short (6" long), window effect no small intestine 6 -7 normal good very large 10 - 14 ft, 80 cm 2 /cm about 3 hours no large intestine 6. 8 - 7 - good not very large 4 - 5 ft long, up to 24 hr lower colon, rectum yes gastric emptying and motility figure 11. 3. generic viagra xl 1 dependence of peak acetaminophen plasma concentration as a function of stomach emptying half-life redrawn from heading, r. C. , nimmo, j. cheap viagra online , prescott, l. Eli lilly viagra F. And tothill, p. 1973. cheap generic viagra The dependence of paracetamol absorption on the rate of gastric emptying, br. J. Indian viagra safe Pharmacol. , 47, 415-421 generally drugs are better absorbed in the small intestine (because of the larger surface area) than in the stomach, therefore quicker stomach emptying will increase drug absorption. For example, a good correlation has been found between stomach emptying time and peak plasma concentration for acetaminophen. The quicker the stomach emptying (shorter stomach emptying time) the higher the plasma concentration, figure 11. 3. viagra one time use 1. buy generic viagra online cheap Also slower stomach emptying can cause increased degradation of drugs in the stomach's lower ph; e. G. L-dopa. Table 11. buying generic viagra on line 3. 2 factors affecting gastric emptying volume of ingested material as volume increases initially an increase then a decrease. Bulky material tends to empty more slowly than liquids type of meal fatty food decrease carbohydrate decrease temperature of food increase in temperature, increase in empyting rate body position lying on the left side decreases emptying rate. viagra 10 mg lutschtabletten Standing versus lying (delayed) drugs anticholinergics (e. G. Atropine), narcotic (e. G. Morphine, alfentanil), analgesic (e. buy viagra online in usa G. generic viagra xl Aspirin) decrease metoclopramide, domperidone, erythromycin, bethanchol (see gastroparesis ref below) increase from mayersohn, m. 1971. Physiological factors influencing drug absorption, can. Pharm. real viagra cheap J. , 164-169 effect of food figure 11. 3. viagra online 2 effect of fasting versus fed on propranolol concentrations melander, a. are viagra soft tabs real , danielson, k. lawrence hilton-jacobs viagra commercial , schersten, b. And wahlin, e. female viagra trial 1977. Enhancement of the bioavailability of propranolol and metaprolol by food, clin. 100 mg generic viagra Pharmacol. Ther. , 22, 108-112 food can effect the rate of gastric emptying. cheap viagra For example fatty food can slow gastric emptying and retard drug absorption. Generally the extent of absorption is not grea. , un nuevo concepto de tienda

 

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